The Moon Glo Hotel was built in the early 1900s known as one of the most well known spots in Buffalo, New York. The hotel was located on the corner of Michigan Avenue and William Street which was down the street from Little Harlem Hotel. Inside the hotel, there was a nightclub called the Moonglow. 

The Moon Glo Hotel and Moonglow was one of the most famous places in Buffalo along with many other well known places. For example, In the early 1930s the Vendome opened and in the mid 1960s the Luck Clover which was a R&B bar. However, in the mid 1940s, the Moonglow was forced to close for a certain period of time due to events going on on the Michigan Strip. Sadly by the 1990s all of the hotels and nightclubs started to close and it wasn't as popular as it used to be.

Then in the early 2000s, the Moonglow Hotel caught on fire killing fifteen children and three adults.